The concentration of copper, zinc, cadmium and lead in human milk of Yemeni women were determined by anodic stripping voltammetry and the daily intake of these elements were calculated. Zn concentrations in Breast milk declined throughout lactation from 3706 ± 1233 µg/l at one month to 816 ± 226 µg/l at 12 month. Cu levels declined from 664 ±139 µg/l at one month to 284 ± 84 µg/l at 12 month with little change thereafter. Based on these data and the volume of milk produced by Yemeni mothers it was estimated that fully breast-fed infants would receive approximately 2151 ± 853 to 815 ± 358 µg zinc and 372 ± 111 to 285 ± 130 µg copper during the first year of lactation. These values are higher than those observed in other poorly nourished countries but are considerably lower than dietary recommendations. The weekly intake of Cd and Pb by Yemeni infants from breast milk alone is below the FAO/WHO Provisional Tolerable Weekly Intake (PTWI). The breast milk of regular khat users had significantly higher concentrations of cadmium and lead, but almost the same amounts of copper and zinc. The concentration of Cu and Zn in breast milk seems to be stabilized via the ability of mammals and vertebrate to maintain homeostasis by a combination of decreased absorption and enhanced excretion. The most dramatic consequence of heavy khat chewing found in this study was a marked decrease in the breast-milk volume of khat-users, which is expected to reduce the daily Zn and Cu intakes of breast-fed infants