The plant seed extracts of Cucumis. sativus and Citrullus. colocynthus are containing glycoprotein
molecules described to be of lectin characters . These lectins were used as possible immunomodulant . The test
immunogen was Mycobaterium tuberculosis PPD and the test immune system was the rabbit with the aim of
proving of any immunomodulating effects .
The C. sativus lectin (Csl) stimulate the secondary humoral immune response and produce leucocyte
inhibitory cytokines in primary , secondary cell mediated immune responses as well as augmentation of skin
DTH reaction in both primary and secondary responses.
The C.eulocvnthus lectin (Ccl) was stimulating to primary and secondary humoral immune responses
as well as it stimulate production of Leucocyte inhibitory cytokines (LIF) both primary and secondary cell
mediated immune responses. It was however, inhibiting to skin DTH reactions in both primary and secondary
responses
Thus Csl and Ccl are of immunomodulating potential in rabbits, Immune system affecting both
humeral and cellular arms.