Metabolism &Transpor t of Membrane Lipids

1) Lipid digestion, absorption and transport
2) Fatty acid oxidation
3) Keton bodies
4) Fatty acid biosynthesis
5) Regulation of fatty acid metabolism
6) Cholesterol metabolism
7) Eicasonoid metabolism
8) Phospholipid and glycolipid metabolism
Lipid Digestion, Absorption and
Transport
Synthesis of FA through condensation of C2 units ->
reversal of ?- oxidation
Cytosolic, NADPH <-> mitochondrial, FAD, NAD
Difference in stereochemistry
C3 unit for growth (malonyl-CoA) <-> C2 for oxidation
(acetyl-CoA)
Growing chain esterified to acyl-carrier protein (ACP)
Esterified to phosphopantetheine group as in CoA which
itself is bound to a Ser on ACP
Synthesis of FA through condensation of C2 units ->
reversal of ?- oxidation
Cytosolic, NADPH <-> mitochondrial, FAD, NAD
Difference in stereochemistry
C3 unit for growth (malonyl-CoA) <-> C2 for oxidation
(acetyl-CoA)
Growing chain esterified to acyl-carrier protein (ACP)
Esterified to phosphopantetheine group as in CoA which
itself is bound to a Ser on ACP
ACP synthase transfers phosphopantetheine to apo-ACP
to form a holo-ACP
ACP synthase transfers phosphopantetheine to apo-ACP
to form a holo-ACP